Background :
@EN NIDDM is characterized by insulin resistance, hyperinsulinemia and frequently associated with hyperinsulinemia and frequently associated with hypertension. The renin aldosterone system is important in the regulation of blood pressure (BP).
Our
primary purpose was investigating the relationship between renin aldosterone system and obesity.
@ES Methods :
@EN Physical examination, anthropometry, blood pressure, C-peptide response during oral glucose tolerance test, ad plasma renin activity (PRA), serum aldosterone (SA) in basal and stimulated states measured in 0 male and 20 female subjects. None
of
the
subjects has autonomic neuropathy, proliferative retinopathy, or advance nephropathy.
@ES Results :
@EN The age of the subjects was 53.1±7.5 (kmean±SD) and the duration of DM was 6.5±4.9 years. The incidence of anthropometric obesity (% IBW≥120) was 36.7% but that of central obesity determined by the waist-to-hip ratio (WHR) was much higher
(60%).
Those with central obesity showed significant suppression of PRA and SA levels at both basal and exercise stimulated state in comparison with those without central obesity. Moreover both diastolic and systolic blood pressures were higher in
centrally
obese group. But dividing the subjects into anthropometrically obese and non-obese subjects, only the basal PRA was significantly lower in obese group compared with non-obese group. The stimulated PRA, basal and stimulated SA levels and the blood
pressures showed no statisticall difference between two groups.
Also the stimulated PRA and SA levels showed negative correlation with serum C-peptide (r=-0.41, p<0.03 and r=-0.46, p<0.03), respectively), and WHR (r=-0.45, p<0.02, r=-0.59, p<0.001, respectively) out basal PRA and SA showed no correlation. In
addition, there was a positive correlation between serum C-peptide and WHR (r=0.51, p<0.005).
@ES Conclusion :
@EN The renin aldosterone system in NIDDM seems to be influenced by the central obesity and the hyperinsulinemic state, and hypertension in centrally obese NIDDM appears to be volume dependent.
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